Mitchell

The Department of Physics, Graduate School of Science, The University of Tokyo invites applications for a tenured faculty position of Associate Professor in experimental soft condensed matter starting at the earliest convenience after April 1, 2018. An Associate Professor in The University of Tokyo is an independent member of the faculty with the freedom to organize his/her own laboratory. We seek outstanding researchers in experimental soft condensed matter which is an interdisciplinary research field of soft material, non-equilibrium statistical mechanics, and biological physics. These areas include: non-equilibrium behavior of soft matter, non-equilibrium phase transitions, stochastic thermodynamics, active matter, hydrodynamics and statistical mechanics of driven/active systems, and physical approach to biological systems.

The successful candidate should have a Ph.D. degree or equivalent, a strong research background, and teaching ability at the graduate school level in soft condensed matter physics. The candidate is expected to demonstrate his/her research ability and excellence, to develop an independent research program at an international level and to teach both undergraduate and graduate courses in Physics. We are committed to promoting the highest standards in scientific research and teaching irrespective of background and are interested in receiving applications from a broad range of candidates. The deadline for applications is August 18, 2017.

Applicants are required to prepare the following documents: (1) curriculum vitae, (2) list of publications, (3) copies of up to five publications, (4) statement of research achievements (up to 2 pages), (5) research plan (up to 2 pages) and (6) two person’s name, address, and e-mail address who agreed with writing reference letters if the personnel committee decided to assess.

For more details see http://www.s.u-tokyo.ac.jp/en/recruit/?id=820

The University of. Tokyo actively promotes gender-equal participation and contributes to the formation of a gender-equal society.

In this project, we will be using near infrared light-activated protein-conjugated nanoparticles to deliver functional proteins and/or siRNA to primary cells via an easily scalable, high-throughput microfluidic system available in my lab. We have already synthesized and demonstrated the protein on hollow gold nanocarrier can be successfully delivered to cells and released via pulsed NIR light directly to the cell cytoplasm (1-6). A poly-histidine tagged recombinant protein is conjugated via thiol linkers to hollow gold nanoshells. The protein-HGN are incubated with cells to internalize the carriers via endocytosis facilitated by the appropriate cell penetrating peptide. Following incubation, the HGN is activated by picosecond NIR light pulses applied during flow of the cells through a microfluidic channel. The HGN carriers adsorb the light energy, which is then converted within picoseconds into “hot electrons” that cleave the thiol bonds linking the HGN to the protein cargo. In the following nanoseconds, the HGN dissipates its heat by vaporizing a minute amount of water, forming vapor nanobubbles (7) that insulate both the cell and cargo from significant temperature changes. In this project, we will work on turning this system into a cell micro-manufacturing platform to efficiently modify the cell of choice via protein or siRNA delivery. Using this method, we can create large volumes of modified cells for use in personalized treatments of disease. Our first goal will be to use NK and T-cell modifications with the CAR protein to prime these cells for immunological treatments of cancer.

Requirements: Ph. D. in Biophysics, Chemical Engineering, Physics, Materials Science or Biochemistry.

Preferred to have previous experience in cell culture, colloid chemistry and physics, biochemistry. Position open immediately.

1. G. B. Braun, T. Friman, H. B. Pang, A. Pallaoro, T. H. de Mendoza, A. M. Willmore, V. R. Kotamraju, A. P. Mann, Z. G. She, K. N. Sugahara, N. O. Reich, T. Teesalu, E. Ruoslahti, Etchable plasmonic nanoparticle probes to image and quantify cellular internalization. Nat. Mater. 13, 904-911 (2014).

2. G. B. Braun, A. Pallaoro, G. Wu, D. Missirlis, J. A. Zasadzinski, M. Tirrell, N. O. Reich, Laser-
activated gene silencing via gold nanoshell-siRNA conjugates. ACS Nano 3, 2007–2015 (2009).

3. N. Forbes, A. Pallaoro, N. O. Reich, J. A. Zasadzinski, Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light. Particle & Particle Systems Characterization 31, 1158- 1167 (2014).

4. X. Huang, Q. Hu, G. B. Braun, A. Pallaoro, D. P. Morales, J. A. Zasadzinski, D. O. Clegg, N. O. Reich, Light-activated RNA interference in human embryonic stem cells. Biomaterials 63, 70-79 (2015).

5. X. Huang, A. Pallaoro, G. B. Braun, D. P. Morales, M. O. Ogunyankin, J. Zasadzinski, N. O. Reich,Modular plasmonic nanocarriers for efficient and targeted delivery of cancer-therapeutic siRNA. Nano Lett 14, 2046-2051 (2014).

6. D. P. Morales, G. B. Braun, A. Pallaoro, R. W. Chen, X. Huang, J. A. Zasadzinski, N. O. Reich, Targeted Intracellular Delivery of Proteins with Spatial and Temporal Control. Molecular Pharmaceutics 12, 600-609 (2015).

7. E. Y. Lukianova-Hleb, A. N. Volkov, D. O. Lapotko, Laser Pulse Duration Is Critical For the
Generation of Plasmonic Nanobubbles. Langmuir 30, 7425-7434 (2014).

Excellent candidates are invited to apply for a postdoctoral researcher position in the Robertson-Anderson lab in the Physics and Biophysics Department at the University of San Diego. The Robertson-Anderson lab specializes in understanding the molecular-level dynamics that give rise to novel physical properties present in soft biological materials. We develop and use force spectroscopy and fluorescence microscopy techniques to characterize molecular transport and microrheological properties of these materials. We also aim to develop new bio-inspired composite materials with novel emergent properties. The open position is for a cutting-edge Air Force project to elucidate the molecular dynamics governing DNA-based composite biomaterials. The postdoc will be responsible for developing instrumentation/techniques as well as DNA purification and fluorescence assays; and designing and executing novel microrheology experiments and analysis. Candidates should have experience with force spectroscopy and image analysis and be well-versed in Matlab and Labview. Knowledge/experience with soft matter physics and molecular biochemistry techniques is preferred. University of San Diego is a primarily undergraduate institution so the postdoc will be expected to help advise undergraduate researchers, and will have opportunities to teach depending on interest and research progress. Candidates should have a PhD in physics although related doctoral degrees will be considered. Applications should include a cover letter, detailed CV, and 3 letters of recommendation. All materials should be emailed to randerson@sandiego.edu. Applications for full consideration are due by April 30, 2017. Applications will be considered until the position is filled.

STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAM

Program Directors: Sandy Napel, PhD and Bruce Daniel, MD

The Stanford Cancer Imaging Training (SCIT) Program, funded by the National Cancer Institute, aims to train the next generation of researchers in the development and clinical translation of advanced techniques for cancer imaging and its application.

This T32 training program is the evolution of the longstanding program, formerly known as “Advanced Techniques for Cancer Imaging and Detection,” established and led by former Radiology Chair, Dr. Gary M. Glazer in 1992.

SCIT is a two-year program training five fellows (roughly half PhD / half MD) per year over a five-year funding cycle. Drs. Sandy Napel and Bruce Daniel lead this newly redesigned program, featuring 24 mentors with independent cancer-focused or -related funding, and seven distinguished program advisors. The strengthened required coursework component includes two courses in the clinical/cancer sciences, two in imaging science, one in biostatistics, one in medical ethics (“Responsible Conduct of Research”), and attendance at a minimum of six multidisciplinary tumor boards. In addition, trainees can select from a multitude of electives offered by various Stanford University Departments, e.g., Radiology, Radiation Oncology, Bioengineering, Biomedical Informatics, and Cancer Systems Biology. The primary focus of the program is participation in a mentored cancer-imaging research project aimed at publication in peer-reviewed journals, and presentation at national meetings. The program especially features “paired mentorship,” in which each trainee is teamed with both a basic-science and physician mentor, to provide guidance in course and research-topic selection, and in performing clinically-relevant cancer imaging research.

Eligibility:
1. Candidate must have an MD or PhD degree.
2. Candidate must be a US citizen, or a non-citizen national, or must have been lawfully admitted for permanent residence and possess an Alien Registration Card (1-151 or 1-551) or some other verification of legal admission as a permanent resident.

Application Deadline: April 10, 2017

The National Academies of Sciences, Engineering, and Medicine sponsors a number of awards for postdoctoral and senior researchers at participating federal laboratories and affiliated institutions. These awards include generous stipends ranging from $45,000 – $80,000 per year for recent Ph.D. recipients, and higher for additional experience. Limited graduate level awards are available. These awards provide the opportunity for recipients to do independent research in some of the best-equipped and staffed laboratories in the U.S. Research opportunities are open to U.S. citizens, permanent residents, and for some of the laboratories, foreign nationals.
**In a previous email, our Call for Applications date incorrectly stated March 1 to May 1, 2015. Please note the dates are March 1 to May 1, 2017. The Support Documents Deadline is May 15, 2017.**
Four annual review cycles:
Review Cycle: May; Opens March 1; Closes May 1
Review Cycle: August; Opens June 1; Closes August 1
Review Cycle: November; Opens September 1; Closes November 1
Review Cycle: February; Opens December 1; Closes February 1
Applicants should contact prospective Adviser(s) at the lab(s) prior to the application deadline to discuss their research interests and funding opportunities.
For more information:
www.nas.edu/rap
rap@nas.edu
202-334-2760

Post-Doctoral Position: Department of Chemical Engineering and Materials
Science, University of Minnesota
beginning immediately
Relating Monolayer Dynamics and Adsorption to Composition and Morphology An essential, function of LS is to prevent the Laplace instability, which drives gas out of smaller alveoli and into larger ones, effectively deflating smaller alveoli and thickening the alveolar lining fluid. The Laplace Instability occurs when the capillary pressure, ΔP=2γ/R, in small alveoli (radius RS) exceeds that of larger alveoli (radius RL): 2γ/RS > 2γ/RL. This post-doctoral position is designed to examine the hypothesis that the dynamic resistance of the LS monolayer to compression can reverse the Laplace instability. The dilatational modulus, 𝜀 𝜔 = 𝐴 𝜔 𝜕𝛾 𝜕𝐴 , relates the change in surface tension, γ, to the change in molecular area, A. For 𝜕 𝛾 𝑅 𝜕𝑅 = 2𝜀 – 𝛾 𝑅! > 0, or 2ε−γ >0, the Laplace pressure decreases with decreasing radius, suppressing the Laplace Instability. However, if 2ε−γ is negative, even small variations in inflation would drive spontaneous collapse of some alveoli, and hyper-extension of others. My group
has designed and built a novel capillary pressure microtensiometer to measure ε. The post-doc will map out ε for clinical and model lung surfactants as a function of surface pressure and frequency to determine the effects of solid phase fraction (related to saturated vs. unsaturated lipid fraction), domain morphology (related to lung surfactant proteins SP-B and SP-C, cholesterol and fatty acid fractions) and subphase compositions of lysolipids and/or albumin. If the Laplace instability does play a causative role in the progression of ARDS, then any successful therapy must reverse this instability. Reversing the Laplace instability requires understanding how to accelerate the interfacial adsorption of LS relative to albumin and lyso-PC, which we propose to
study using confocal microscopy.
The ideal applicant would be a trained experimentalist with a background in the physics and chemistry of interfacial phenomena. Prior experience with confocal or two-photon microscopy, design of experimental apparatus, Labview experience, handling and preparing lipid and protein mixtures, atomic force microscopy, Langmuir isotherms.
Previous students and post-docs on this project have gone on to careers in both industry and academia.
Salary: $42-45K depending on experience + benefits. Minimum duration one year, with extension depending on progress. Applications should be send to Joseph Zasadzinski (biosketch/CV + career plans + names of two referees or two recommendation letters). Position open until filled.

The Department of Chemistry and Biochemistry at the University of Delaware invites applications for a continuing non-tenure track faculty position at the rank of assistant professor beginning September 1, 2017. The primary responsibility of this position is general chemistry for STEM majors, with the opportunity to teach honors and courses in other areas depending on the candidate’s experience and expertise. Applicants should possess strong content knowledge in the chemical sciences, demonstrated commitment to the use of evidence-based teaching methods, and an interest in pursuing scholarly activities associated with teaching and learning. Applicants must have a Ph.D. in chemistry, biochemistry, or a related field.
An innovative leader in teaching and research, the University of Delaware combines a rich historic legacy with a commitment to undergraduate education and the creation of new impactful knowledge. The main campus in Newark, Delaware provides the amenities of a vibrant college town with convenient access to the major cities of the East Coast. The Department of Chemistry and Biochemistry consistently ranks among the top 10 institutions nationwide in ACS certified degrees, and over 80% of our undergraduates engage in research prior to graduation.
Applicant Instructions
Applicants should apply on-line at http://apply.interfolio.com/ and should submit a letter of application, a curriculum vitae, a statement of teaching philosophy and professional development goals, and arrange for submission of at least three letters of recommendation. Review of applications will begin on February 1, 2016 and will continue until the position is filled. All application materials will be shared with departmental faculty. Questions should be directed to Ms. Susan Cheadle at: scheadle@udel.edu.
Employment offers will be conditioned upon successful completion of a criminal background check. A conviction will not necessarily exclude you from employment.
The University of Delaware is an equal opportunity/affirmative action employer and Title IX institution. For the University’s complete non-discrimination statement, please visit http://www.udel.edu/home/legal-notices/